LEVOFLOXACIN
Please note levofloxacin is not licensed for the treatment of tuberculosis in the UK.
DOSAGE
Adults: 10–15 mg/kg once daily (usually 750mg to 1000mg once daily).
Children: 15-20mg/kg once daily.
PREPARATIONS
Oral: 250mg, 500mg tablets.
Parenteral: 400mg/100mL solution for infusion.
DRUG LEVEL MONITORING
Indications for monitoring:
0.5 – 2 mg/L (trough).
Timing of sample:
ADVERSE EFFECTS
COMMON:
Gastrointestinal: Nausea, vomiting, diarrhoea.
Other: Dizziness, headache.
Hepatic: Transient increases in LFTs.
SERIOUS:
Cardiovascular: QTc prolongation (rare; more common in hypokalaemia, and predisposing cardiac conditions).
Dermatological: Stevens-Johnson syndrome or toxic epidermal necrolysis (rare).
Metabolic: Hypoglycaemia (in patients on hypoglycaemic drugs, uncommon).
Haematologic: Eosinophilia, leucopaenia (uncommon), thrombocytopaenia, neutropaenia (rare).
Hepatic: Acute hepatitis (rare).
Immunological: Anaphylaxis, immune hypersensitivity (uncommon).
Musculoskeletal: Tendon inflammation and rupture (see contra-indications below).
Neurological: Seizures (caution in patients with CNS disorders).
Renal: Renal impairment (rare).
ADVERSE EFFECTS: MONITORING
ECG: Baseline, 2 weeks then every 3 months and after the addition of any new medication that is known to prolong QT.
LFTs, U&Es and FBC should also be monitored sporadically throughout treatment. No specific frequency recommendations but generic monitoring guidelines should be frequent enough.
Routine tests as per generic MDR-TB treatment monitoring guidelines.
INTERACTONS
Amiodarone: Increased risk of ventricular arrhythmia.
Antacids: Reduced absorption of levofloxacin.
Anticoagulants: Possible enhanced effect of coumarins (e.g. warfarin) and phenindione.
Ciclosporin: Increased risk of nephropathy.
Iron: Reduced absorption of levofloxacin.
NSAIDS: Possible increased risk of convulsions.
Theophylline: Increased risk of convulsions. Reduce dose of theophylline and monitor levels.
Zinc: Reduced absorption of levofloxacin.
Drugs known to prolong the QT interval: use with caution in patients taking Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics.
This information is not inclusive of all drug interactions. Please discuss with a pharmacist.
CONTRA-INDICATIONS & CAUTIONS
Contraindications:
Hypersensitivity: To levofloxacin or other quinolones.
Epilepsy/Seizure Activity: May induce convulsions in patients with or without history of convulsions, use with caution if epileptic or conditions predisposing seizures.
Tendon Damage: Rarely reported but damage or rupture may occur within 48 hours of treatment and several months after stopping treatment. Increased risk in patients with a history of tendon disorders related to quinolone use, aged over 60 years, concomitant use of corticosteroids. Cease all quinolone treatment if tendinitis suspected.
Pregnancy: Avoid in pregnancy, animal studies have shown quinolones cause arthropathy.
Breast Feeding: Avoid, present in milk in animal studies.
Children: Levofloxacin is contra-indicated in the UK for use in children or growing adolescents. Use in TB with caution. Arthropathy has developed in weight-bearing joints in young animals.
Cautions:
May impair performance of skilled tasks such as driving
Long QT Syndrome: Can prolong QT interval. Use with caution in patients with risk factors for QT interval prolongations.
Myasthenia Gravis: Risk of exacerbation.
G6PD deficiency: Risk of haemolytic reactions when treated with quinolones.
Liver Disease: Monitor LFTs.
Renal Disease: Reduce dose in renal impairment.
Sunlight: Risk of photosensitivity reaction.
Serious bullous skin reactions: Risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.
Peripheral Neuropathy: Sensorimotor polyneuropathy resulting in paraesthesias, hypoaesthesias, dysaesthesias, or weakness.
LABORATORY INFORMATION
Please find up to date information at www.assayfinder.com regarding individual providers of drug level monitoring tests. Click on the provider to discover contact details. Turnaround time varies depending on the test and whether it is run locally or sent to an external lab. By contacting laboratories in advance, turnaround time can significantly be reduced.
Sample Type: Serum.
Volume Required: Ideally 2ml (min 0.1mL).
Sample Container: Plain glass or plastic (non SST).
Container Type: Any.
Availability: NS.
Turnaround Time: Telephoned same day if received 9am-3pm Mon-Fri if advanced warning given. Written confirmation report will be sent by 1st Class post
The sample must be heat-treated before dispatch if HIV positive.
Please telephone at least one day in advance of the sample.
- Despite the lack of data establishing the safety and efficacy of fluoroquinolone use in children they continue to be used to treat MDR-TB in children of all ages in clinical practice. It is felt the benefit of treatment of MDR-TB outweighs the small potential risk of adverse reactions.
- If using a flouroquinolone we would recommend moxifloxacin as first choice agent followed by levofloxacin.
DOSAGE
Adults: 10–15 mg/kg once daily (usually 750mg to 1000mg once daily).
Children: 15-20mg/kg once daily.
PREPARATIONS
Oral: 250mg, 500mg tablets.
Parenteral: 400mg/100mL solution for infusion.
DRUG LEVEL MONITORING
Indications for monitoring:
- Known or suspected malabsorption.
- Poor treatment response.
0.5 – 2 mg/L (trough).
Timing of sample:
- 2 hours post oral dose (or 1 hour after the end of intravenous infusion).
- Repeat at 6 hours if suspect delayed absorption.
- Consider taking a trough level.
- Drug levels need not be routinely measured.
ADVERSE EFFECTS
COMMON:
Gastrointestinal: Nausea, vomiting, diarrhoea.
Other: Dizziness, headache.
Hepatic: Transient increases in LFTs.
SERIOUS:
Cardiovascular: QTc prolongation (rare; more common in hypokalaemia, and predisposing cardiac conditions).
Dermatological: Stevens-Johnson syndrome or toxic epidermal necrolysis (rare).
Metabolic: Hypoglycaemia (in patients on hypoglycaemic drugs, uncommon).
Haematologic: Eosinophilia, leucopaenia (uncommon), thrombocytopaenia, neutropaenia (rare).
Hepatic: Acute hepatitis (rare).
Immunological: Anaphylaxis, immune hypersensitivity (uncommon).
Musculoskeletal: Tendon inflammation and rupture (see contra-indications below).
Neurological: Seizures (caution in patients with CNS disorders).
Renal: Renal impairment (rare).
ADVERSE EFFECTS: MONITORING
ECG: Baseline, 2 weeks then every 3 months and after the addition of any new medication that is known to prolong QT.
LFTs, U&Es and FBC should also be monitored sporadically throughout treatment. No specific frequency recommendations but generic monitoring guidelines should be frequent enough.
Routine tests as per generic MDR-TB treatment monitoring guidelines.
INTERACTONS
Amiodarone: Increased risk of ventricular arrhythmia.
Antacids: Reduced absorption of levofloxacin.
Anticoagulants: Possible enhanced effect of coumarins (e.g. warfarin) and phenindione.
Ciclosporin: Increased risk of nephropathy.
Iron: Reduced absorption of levofloxacin.
NSAIDS: Possible increased risk of convulsions.
Theophylline: Increased risk of convulsions. Reduce dose of theophylline and monitor levels.
Zinc: Reduced absorption of levofloxacin.
Drugs known to prolong the QT interval: use with caution in patients taking Class IA and III anti-arrhythmics, tricyclic antidepressants, macrolides, antipsychotics.
This information is not inclusive of all drug interactions. Please discuss with a pharmacist.
CONTRA-INDICATIONS & CAUTIONS
Contraindications:
Hypersensitivity: To levofloxacin or other quinolones.
Epilepsy/Seizure Activity: May induce convulsions in patients with or without history of convulsions, use with caution if epileptic or conditions predisposing seizures.
Tendon Damage: Rarely reported but damage or rupture may occur within 48 hours of treatment and several months after stopping treatment. Increased risk in patients with a history of tendon disorders related to quinolone use, aged over 60 years, concomitant use of corticosteroids. Cease all quinolone treatment if tendinitis suspected.
Pregnancy: Avoid in pregnancy, animal studies have shown quinolones cause arthropathy.
Breast Feeding: Avoid, present in milk in animal studies.
Children: Levofloxacin is contra-indicated in the UK for use in children or growing adolescents. Use in TB with caution. Arthropathy has developed in weight-bearing joints in young animals.
Cautions:
May impair performance of skilled tasks such as driving
Long QT Syndrome: Can prolong QT interval. Use with caution in patients with risk factors for QT interval prolongations.
Myasthenia Gravis: Risk of exacerbation.
G6PD deficiency: Risk of haemolytic reactions when treated with quinolones.
Liver Disease: Monitor LFTs.
Renal Disease: Reduce dose in renal impairment.
Sunlight: Risk of photosensitivity reaction.
Serious bullous skin reactions: Risk of Stevens-Johnson syndrome or toxic epidermal necrolysis.
Peripheral Neuropathy: Sensorimotor polyneuropathy resulting in paraesthesias, hypoaesthesias, dysaesthesias, or weakness.
LABORATORY INFORMATION
Please find up to date information at www.assayfinder.com regarding individual providers of drug level monitoring tests. Click on the provider to discover contact details. Turnaround time varies depending on the test and whether it is run locally or sent to an external lab. By contacting laboratories in advance, turnaround time can significantly be reduced.
Sample Type: Serum.
Volume Required: Ideally 2ml (min 0.1mL).
Sample Container: Plain glass or plastic (non SST).
Container Type: Any.
Availability: NS.
Turnaround Time: Telephoned same day if received 9am-3pm Mon-Fri if advanced warning given. Written confirmation report will be sent by 1st Class post
The sample must be heat-treated before dispatch if HIV positive.
Please telephone at least one day in advance of the sample.